Getting to Mars will make a trip to the moon seem like a piece of cake. Along with the daunting engineering problems that will have to be solved before humans can travel to the Red Planet, a number of biomedical concerns will also need to be addressed. Particular attention will have to be paid to protecting crews from space radiation and providing them with oxygen, water and food during the long journey. While shielding crews from radiation is a primary concern of engineers, providing people with life supplies in flight is an area for biomedical specialists. In Russia specialists of the Institute of Biomedical problems (IBMP) have developed a concept for a closed-loop life-support system (LSS) for interplanetary voyages.